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Total 140396 results found since Jan 2013.
Identification of ILK as a critical regulator of VEGFR3 signalling and lymphatic vascular growth
Vascular endothelial growth factor receptor-3 (VEGFR3) signalling promotes lymphangiogenesis. While there are many reported mechanisms of VEGFR3 activation, there is little understanding of how VEGFR3 signalling is attenuated to prevent lymphatic vascular overgrowth and ensure proper lymph vessel development. Here, we show that endothelial cell-specific depletion of integrin-linked kinase (ILK) in mouse embryos hyper-activates VEGFR3 signalling and leads to overgrowth of the jugular lymph sacs/primordial thoracic ducts, oedema and embryonic lethality. Lymphatic endothelial cell (LEC)-specific deletion of Ilk in adult mice ...
Source: EMBO Journal - January 15, 2019 Category: Molecular Biology Authors: Urner, S., Planas-Paz, L., Hilger, L. S., Henning, C., Branopolski, A., Kelly-Goss, M., Stanczuk, L., Pitter, B., Montanez, E., Peirce, S. M., Mäkinen, T., Lammert, E. Tags: Development & Differentiation, Signal Transduction, Vascular Biology & Angiogenesis Articles Source Type: research
TFEB controls vascular development by regulating the proliferation of endothelial cells
Transcription factor TFEB is thought to control cellular functions—including in the vascular bed—primarily via regulation of lysosomal biogenesis and autophagic flux. Here, we report that TFEB also orchestrates a non-canonical program that controls the cell cycle/VEGFR2 pathway in the developing vasculature. In endothelial cells, TFEB depletion halts proliferation at the G1-S transition by inhibiting the CDK4/Rb pathway. TFEB-deficient cells attempt to compensate for this limitation by increasing VEGFR2 levels at the plasma membrane via microRNA-mediated mechanisms and controlled membrane trafficking. TFEB stim...
Source: EMBO Journal - February 1, 2019 Category: Molecular Biology Authors: Doronzo, G., Astanina, E., Cora, D., Chiabotto, G., Comunanza, V., Noghero, A., Neri, F., Puliafito, A., Primo, L., Spampanato, C., Settembre, C., Ballabio, A., Camussi, G., Oliviero, S., Bussolino, F. Tags: Cell Cycle, Transcription, Vascular Biology & Angiogenesis Articles Source Type: research
RNA editing of Filamin A pre-mRNA regulates vascular contraction and diastolic blood pressure
Epitranscriptomic events such as adenosine-to-inosine (A-to-I) RNA editing by ADAR can recode mRNAs to translate novel proteins. Editing of the mRNA that encodes actin crosslinking protein Filamin A (FLNA) mediates a Q-to-R transition in the interactive C-terminal region. While FLNA editing is conserved among vertebrates, its physiological function remains unclear. Here, we show that cardiovascular tissues in humans and mice show massive editing and that FLNA RNA is the most prominent substrate. Patient-derived RNA-Seq data demonstrate a significant drop in FLNA editing associated with cardiovascular diseases. Using mice w...
Source: EMBO Journal - October 1, 2018 Category: Molecular Biology Authors: Jain, M., Mann, T. D., Stulic, M., Rao, S. P., Kirsch, A., Pullirsch, D., Strobl, X., Rath, C., Reissig, L., Moreth, K., Klein-Rodewald, T., Bekeredjian, R., Gailus-Durner, V., Fuchs, H., Hrabe de Angelis, M., Pablik, E., Cimatti, L., Martin, D., Zinnanti Tags: Development & Differentiation, RNA Biology, Vascular Biology & Angiogenesis Articles Source Type: research
Serum/glucocorticoid-regulated kinase 1 as a novel transcriptional target of bone morphogenetic protein-ALK1 receptor signaling in vascular endothelial cells
AbstractBone morphogenetic protein 9 (BMP9)/BMP10-ALK1 receptor signaling is essential for endothelial differentiation and vascular morphogenesis. Mutations inALK1/ACVRL1 and other signal-related genes are implicated in human vascular diseases, and theAlk1/Acvrl1 deletion in mice causes severe impairment of vascular formation and embryonic lethality. In the microarray screen to search for novel downstream genes of ALK1 signaling, we found that the mRNA and protein expression of serum/glucocorticoid-regulated kinase 1 (SGK1) was rapidly up-regulated by the BMP9 stimulation of cultured human endothelial cells. The increase i...
Source: Angiogenesis - February 24, 2018 Category: Molecular Biology Source Type: research
Serratiopeptidase Attenuates < em > Lipopolysaccharide < /em > -Induced Vascular Inflammation by Inhibiting the Expression of Monocyte Chemoattractant Protein-1
In conclusion, SRP has the ability to reduce LPS-induced vascular inflammation and damage by modulating MCP-1.PMID:36975512 | PMC:PMC10047379 | DOI:10.3390/cimb45030142
Source: Current Issues in Molecular Biology - March 28, 2023 Category: Molecular Biology Authors: Vikas Yadav Satyam Sharma Ashutosh Kumar Sanjiv Singh V Ravichandiran Source Type: research
